VARIATIONS IN SOLID-PHASE EXTRACTION OF BASIC DRUGS USING BONDED SILICA .1. MANUFACTURER-TO-MANUFACTURER VARIATIONS

被引：10

作者：

MARKO, V

RADOVA, K

机构：

[1] Institute of Experimental Pharmacology, Slovak Academy of Sciences, CS-84216, Bratislava

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 09期

关键词：

D O I：

10.1080/01483919108049642

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Manufacturer-to-manufacturer variations of solid-phase extraction (SPE) of basic drugs from serum and water using C18-silica were studied and solute-sorbent interactions discussed on the basis of elution profiles obtained after elution of two model drugs from C18-sorbents of five vendors. In addition to manfacturer-to-manufacturer variations, differences were observed also after SPE from water and from serum indicating an inclusion of endogens from serum to processes run in SPE. Differences in polar properties of the sorbents were found to be the main cause of the variations.

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页码：1645 / 1658

页数：14

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