PREVENTION OF XENOGRAFT REJECTION BY MASKING DONOR HLA CLASS-I ANTIGENS

被引：103

作者：

FAUSTMAN, D ^{[1
]}

COE, C ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DIABET UNIT,BOSTON,MA 02114

来源：

SCIENCE | 1991年 / 252卷 / 5013期

关键词：

D O I：

10.1126/science.1710828

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Destruction of target cells by cytotoxic T lymphocytes requires the presence of HLA (human lymphocyte antigen) class I antigens on the target cells for adhesion as well as for triggering of the antigen-specific T cell receptor. Rejection of xenogeneic human pancreatic islets and liver was circumvented by masking, before transplantation, donor antigens with F(ab')2 antibody fragments to HLA class I or tissue-specific epitopes. This strategy eliminated the need for recipient immunosuppression and allowed islet xenograft survival beyond 200 days, as demonstrated functionally by C peptide secretion as well as by histology. These in vivo observations are consistent with the importance of donor HLA class I in eliciting graft rejection and have potential applicability to the successful transplantation of other HLA class I-bearing donor tissues.

引用

页码：1700 / 1702

页数：3

共 26 条

[1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].

ACHAORBEA, H ;

MITCHELL, DJ ;

TIMMERMANN, L ;

WRAITH, DC ;

TAUSCH, GS ;

WALDOR, MK ;

ZAMVIL, SS ;

MCDEVITT, HO ;

STEINMAN, L .

CELL, 1988, 54 (02) :263-273

[2] INVIVO COMPETITION BETWEEN SELF PEPTIDES AND FOREIGN ANTIGENS IN T-CELL ACTIVATION [J].

ADORINI, L ;

MULLER, S ;

CARDINAUX, F ;

LEHMANN, PV ;

FALCIONI, F ;

NAGY, ZA .

NATURE, 1988, 334 (6183) :623-625

[3] TUMORIGENICITY OF CELLS TRANSFORMED BY ADENOVIRUS-TYPE-12 BY EVASION OF T-CELL IMMUNITY [J].

BERNARDS, R ;

SCHRIER, PI ;

HOUWELING, A ;

BOS, JL ;

VANDEREB, AJ ;

ZIJLSTRA, M ;

MELIEF, CJM .

NATURE, 1983, 305 (5937) :776-779

[4] PREVENTION OF DIABETES IN NONOBESE DIABETIC MICE BY ANTI-I-A MONOCLONAL-ANTIBODIES - TRANSFER OF PROTECTION BY SPLENIC T-CELLS [J].

BOITARD, C ;

BENDELAC, A ;

RICHARD, MF ;

CARNAUD, C ;

BACH, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9719-9723

[5]

BROSTOFF SW, 1984, J IMMUNOL, V133, P1938

[6] INTERCELLULAR-ADHESION MOLECULE-1 IS INDUCED ON ISOLATED ENDOCRINE ISLET CELLS BY CYTOKINES BUT NOT BY REOVIRUS INFECTION [J].

CAMPBELL, IL ;

CUTRI, A ;

WILKINSON, D ;

BOYD, AW ;

HARRISON, LC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) :4282-4286

[7] TRANSPLANTABLE INSULINOMA IN RAT [J].

CHICK, WL ;

WARREN, S ;

CHUTE, RN ;

LIKE, AA ;

LAURIS, V ;

KITCHEN, KC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) :628-632

[8] IMMUNOLOGICAL SURVEILLANCE OF TUMORS IN THE CONTEXT OF MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION OF T-CELL FUNCTION [J].

DOHERTY, PC ;

KNOWLES, BB ;

WETTSTEIN, PJ .

ADVANCES IN CANCER RESEARCH, 1984, 42 :1-65

[9]

FABRE JW, 1975, TRANSPLANTATION, V20, P269

[10] PROLONGATION OF MURINE ISLET ALLOGRAFT SURVIVAL BY PRETREATMENT OF ISLETS WITH ANTIBODY DIRECTED TO IA DETERMINANTS [J].

FAUSTMAN, D ;

HAUPTFELD, V ;

LACY, P ;

DAVIE, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :5156-5159

← 1 2 3 →