CYTOTOXIC EFFECT OF HEMOLYTIC CULTURE SUPERNATANT FROM ENTEROCOCCUS-FAECALIS ON MOUSE POLYMORPHONUCLEAR NEUTROPHILS AND MACROPHAGES

被引：47

作者：

MIYAZAKI, S

OHNO, A

KOBAYASHI, I

UJI, T

YAMAGUCHI, K

GOTO, S

机构：

[1] Department of Microbiology, Toho University School of Medicine, Tokyo 143, Ota-ku

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 37卷 / 04期

关键词：

ENTEROCOCCUS-FAECALIS; RECEPTOR; HEMOLYSIN; CYTOTOXICITY;

D O I：

10.1111/j.1348-0421.1993.tb03209.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reconfirmed that the LD50s of hemolytic Enterococcus faecalis strains were significantly less than those of nonhemolytic E. faecalis strains in normal mice. Hemolysin produced by E. faecalis lysed human, horse, rabbit, and mouse erythrocytes, but not cow and sheep erythrocytes. Sphingomyelin comprises a part of the lipid composition of the erythrocyte membrane of all mammalian species tested. But phosphatidylcholine exists only in human, horse, rabbit, and mouse. These two lipids inhibited lysis of horse erythrocytes by hemolytic E. faecalis. Phosphatidylcholine is probably the binding component on the membrane of erythrocytes for E. faecalis hemolysin. The hemolytic culture supernatant lysed not only erythrocytes but also mouse polymorphonuclear neutrophils (PMNs) and macrophages.

引用

页码：265 / 270

页数：6

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