CHANGES IN OPTIC DISK CHARACTERISTICS AND THE NUMBER OF NERVE-FIBERS IN EXPERIMENTAL GLAUCOMA

被引:46
作者
VARMA, R [1 ]
QUIGLEY, HA [1 ]
PEASE, ME [1 ]
机构
[1] JOHNS HOPKINS UNIV HOSP,WILMER OPHTHALMOL INST,DANA CTR PREVENT OPHTHALMOL,BALTIMORE,MD 21205
关键词
D O I
10.1016/S0002-9394(14)74482-4
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We compared the change in cup/disk ratio and neuroretinal rim area-to-disk area to estimated change in the number of optic nerve fibers in 12 cynomolgus monkeys with unilateral experimental glaucoma. Changes in the cup/disk ratios and neuroretinal rim area-to-disk area were estimated from stereoscopic optic disk photographs that were obtained before and after the development of increased intraocular pressure. Change in the number of optic nerve fibers in the glaucomatous nerves was estimated by comparing them to their fellow normal nerves. A significant linear correlation was present between change in the cup/disk ratios and neuroretinal rim area-to-disk area, and estimated change in the number of optic nerve fibers (r greater-than-or-equal-to .85; P < .0002). In optic disks with initial cup/disk ratios of 0.2 to 0.3 and neuroretinal rim area-to-disk area of 0.9, an increase in the cup/disk ratio of 0.1 and a decrease of 0.1 in the neuroretinal rim area-to-disk area is associated with a 10% and 9% loss of optic nerve fibers, respectively.
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页码:554 / 559
页数:6
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