POLYCYCLIC GUANIDINE-CONTAINING COMPOUNDS FROM THE MEDITERRANEAN SPONGE CRAMBE-CRAMBE - THE STRUCTURE OF 13,14,15-ISOCRAMBESCIDIN 800 AND THE ABSOLUTE STEREOCHEMISTRY OF THE PENTACYCLIC GUANIDINE MOIETIES OF THE CRAMBESCIDINS

被引:98
作者
JARESERIJMAN, EA
INGRUM, AL
CARNEY, JR
RINEHART, KL
SAKAI, R
机构
[1] UNIV ILLINOIS,ROGER ADAMS LAB,URBANA,IL 61801
[2] UNIV HAWAII MANOA,DEPT CHEM,HONOLULU,HI 96822
关键词
D O I
10.1021/jo00070a012
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The absolute stereochemistry of the pentacyclic guanidine moieties of crambescidin 816 (1)1 and of 13,14,15-isocrambescidin 800 (4), a new member of this family, was determined, based on chiral GC analysis of a derivative of 2-hydroxybutanoic acid, an ozonolysis product of the crambescidins. Significantly less antiviral activity and cytotoxicity were observed for 4.
引用
收藏
页码:4805 / 4808
页数:4
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