FURTHER EVIDENCE FOR THE INTERACTION OF THE ANTIMALARIAL DRUG AMODIAQUINE WITH FERRIPROTOPORPHYRIN-IX

被引：20

作者：

BLAUER, G ^{[1
]}

AKKAWI, M ^{[1
]}

BAUMINGER, ER ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, RACAH INST PHYS, IL-91904 JERUSALEM, ISRAEL

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 09期

关键词：

D O I：

10.1016/0006-2952(93)90325-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mossbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.

引用

页码：1573 / 1576

页数：4

共 13 条

[1] MOSSBAUER STUDIES OF FERRIHEME-QUINIDINE COMPLEXES [J].

BAUMINGER, ER ;

MAY, L ;

BLAUER, G .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1988, 151 (04) :277-280

[2]

BLAUER G, 1988, BIOCHEM INT, V17, P729

[3] OPTICAL-PROPERTIES OF COMPLEXES OF ANTIMALARIAL-DRUGS WITH FERRIPROTOPORPHYRIN-IX IN AQUEOUS-MEDIUM .2. THE SYSTEM FERRIPROTOPORPHYRIN-IX-QUINIDINE [J].

BLAUER, G .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 251 (01) :315-322

[4]

BLAUER G, 1982, BIOCHEM INT, V5, P519

[5]

BLAUER G, 1986, ARCH BIOCHEM BIOPHYS, V251, P306, DOI 10.1016/0003-9861(86)90078-0

[6] SOLUTION STRUCTURES OF FERRIHAEM IN SOME DIPOLAR APROTIC SOLVENTS AND THEIR BINARY AQUEOUS MIXTURES [J].

BROWN, SB ;

LANTZKE, IR .

BIOCHEMICAL JOURNAL, 1969, 115 (02) :279-&

[7]

COHEN RL, 1974, METHODS EXPT PHYSICS, V11, P307

[8]

FITCH CD, 1983, CIBA F SYMP, V94, P222

[9] ANTIMALARIAL SCHIZONTOCIDES - FERRIPROTOPORPHYRIN-IX INTERACTION HYPOTHESIS [J].

FITCH, CD .

PARASITOLOGY TODAY, 1986, 2 (12) :330-331

[10] INHIBITION BY CHLOROQUINE OF A NOVEL HEME POLYMERASE ENZYME-ACTIVITY IN MALARIA TROPHOZOITES [J].

SLATER, AFG ;

CERAMI, A .

NATURE, 1992, 355 (6356) :167-169

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