A COMMON STEM-CELL FOR MURINE CORTICAL AND MEDULLARY THYMIC EPITHELIAL-CELLS

被引:38
作者
ROPKE, C
VANSOEST, P
PLATENBURG, PP
VANEWIJK, W
机构
[1] ERASMUS UNIV ROTTERDAM,DEPT IMMUNOL,3000 DR ROTTERDAM,NETHERLANDS
[2] UNIV COPENHAGEN,PANUM INST,DEPT MED ANAT A,CELLULAR IMMUNOL LAB,DK-2200 COPENHAGEN N,DENMARK
来源
DEVELOPMENTAL IMMUNOLOGY | 1995年 / 4卷 / 02期
关键词
FETAL CELL CULTURE; FETAL MURINE THYMUS; STEM CELL; THYMIC EPITHELIUM;
D O I
10.1155/1995/23168
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have addressed the question whether the epithelial stroma in the thymus is derived from a common stem cell or whether cortical and medullary epithelial cells are derived from different embryonic stem cells emerging, for example, from endoderm and ectoderm. By the use of rapidly expanding cultures of thymic epithelial cells (TEC) from 14 to 16 day-old murine fetuses and by specific antibodies against cortical and medullary epithelium, respectively, we were able to demonstrate a small subpopulation of double-labeled TEC in the cultures. These cells were not present in TEC cultures initiated from thymuses of neonatal mice. Double-labeled TEC were also found in tissue sections from fetal thymuses. These findings may indicate that TEC populations of the cortex and the medulla are derived from a common stem cell, with potential for differentiation toward both cortical and medullary TEC.
引用
收藏
页码:149 / 156
页数:8
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