NMDA ANTAGONIST NEUROTOXICITY - MECHANISM AND PREVENTION

被引：765

作者：

OLNEY, JW ^{[1
]}

LABRUYERE, J ^{[1
]}

WANG, G ^{[1
]}

WOZNIAK, DF ^{[1
]}

PRICE, MT ^{[1
]}

SESMA, MA ^{[1
]}

机构：

[1] UNIV MISSOURI,SCH OPTOMETRY,ST LOUIS,MO 63110

来源：

SCIENCE | 1991年 / 254卷 / 5037期

关键词：

D O I：

10.1126/science.1835799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, including phencyclidine (PCP) and ketamine, protect against brain damage in neurological disorders such as stroke. However, these agents have psychotomimetic properties in humans and morphologically damage neurons in the cerebral cortex of rats. It is now shown that the morphological damage can be prevented by certain anticholinergic drugs or by diazepam and barbiturates, which act at the gamma-aminobutyric acid (GABA) receptor-channel complex and are known to suppress the psychotomimetic symptoms caused by ketamine. Thus, it may be possible to prevent the unwanted side effects of NMDA antagonists, thereby enhancing their utility as neuroprotective drugs.

引用

页码：1515 / 1518

页数：4

共 25 条

[1] KINETIC-PROPERTIES OF THE PENTOBARBITAL-GATED CHLORIDE CURRENT IN FROG SENSORY NEURONS [J].