STRUCTURAL CHARACTERIZATION OF THE MAJOR COVALENT ADDUCT FORMED INVITRO BETWEEN ACETAMINOPHEN AND BOVINE SERUM-ALBUMIN

被引:43
作者
HOFFMANN, KJ [1 ]
STREETER, AJ [1 ]
AXWORTHY, DB [1 ]
BAILLIE, TA [1 ]
机构
[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,SEATTLE,WA 98195
关键词
D O I
10.1016/S0009-2797(85)80093-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:155 / 172
页数:18
相关论文
共 19 条
[1]  
AHNFELT NO, 1982, ACTA PHARM SUEC, V19, P367
[2]   LIVER NECROSIS FROM PARACETAMOL [J].
BOYD, EM ;
BERECZKY, GM .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 26 (03) :606-&
[3]  
BROWN JR, 1976, FED PROC, V35, P2141
[4]   SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN [J].
DAHLIN, DC ;
NELSON, SD .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :885-886
[5]   N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].
DAHLIN, DC ;
MIWA, GT ;
LU, AYH ;
NELSON, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331
[6]   DERIVATIZATION OF CATECHOLAMINES IN AQUEOUS-SOLUTION FOR QUANTITATIVE-ANALYSIS IN BIOLOGICAL-FLUIDS [J].
DEJONG, APJM ;
CRAMERS, CA .
JOURNAL OF CHROMATOGRAPHY, 1983, 276 (02) :267-278
[7]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[8]   PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J].
GILLETTE, JR .
BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) :2785-2794
[9]   GAS-CHROMATOGRAPHY OF EPINEPHRINE AND NOREPINEPHRINE AFTER DERIVATIZATION WITH CHLOROFORMATES IN AQUEOUS-MEDIA [J].
GYLLENHAAL, O ;
JOHANSSON, L ;
VESSMAN, J .
JOURNAL OF CHROMATOGRAPHY, 1980, 190 (02) :347-357
[10]  
HINSON JA, 1982, DRUG METAB DISPOS, V10, P47