1-NAPHTHYLPIPERAZINE DERIVATIVES AS POTENTIAL ATYPICAL ANTIPSYCHOTIC AGENTS

被引：58

作者：

LOWE, JA

SEEGER, TF

NAGEL, AA

HOWARD, HR

SEYMOUR, PA

HEYM, JH

EWING, FE

NEWMAN, ME

SCHMIDT, AW

FURMAN, JS

VINCENT, LA

MALONEY, PR

ROBINSON, GL

REYNOLDS, LS

VINICK, FJ

机构：

[1] Central Research Division, Pfizer, Inc., Groton, Connecticut 06340, Eastern Point Road

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 06期

关键词：

D O I：

10.1021/jm00110a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic surrogates for the catechol moiety of dopamine. Compound 4b from this series showed a biochemical profile that translated to behavioral activity in the rat predictive of an antipsychotic agent with a low propensity to cause extrapyramidal side effects in man.

引用

页码：1860 / 1866

页数：7

共 21 条

[1] L-TRYPTOPHAN AS A SELECTIVE HISTOCHEMICAL MARKER FOR SEROTONERGIC NEURONS IN SINGLE-CELL RECORDING STUDIES [J].