SURFACE-ENHANCED RAMAN-SCATTERING ANALYSIS OF ETHENO ADDUCTS OF ADENINE

被引：7

作者：

HELMENSTINE, AM

LI, YS

VODINH, T

机构：

[1] OAK RIDGE NATL LAB, DIV HLTH & SAFETY RES, ADV MONITORING DEV GRP, OAK RIDGE, TN 37831 USA

[2] UNIV TENNESSEE, OAK RIDGE GRAD SCH BIOMED SCI, DIV BIOL, OAK RIDGE NATL LAB, OAK RIDGE, TN 37831 USA

来源：

VIBRATIONAL SPECTROSCOPY | 1993年 / 4卷 / 03期

关键词：

RAMAN SPECTROMETRY; ADENINE; DNA; ETHENO ADDUCTS; VINYL CHLORIDE;

D O I：

10.1016/0924-2031(93)80009-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report surface-enhanced Raman spectroscopy (SERS) detection and analysis of several etheno adducts formed from the metabolism of vinyl chloride: 1,N6-ethenoadenine, 1,N6-ethenoadenosine, and 1,N6-etheno-2'-deoxyadenosine. Spectra of the etheno adducts are compared with unmodified adenine and 2'-deoxyadenosine. Chemical group assignments are made for the SERS peaks of these adducts and the limit at which SERS can detect the adducts is assessed. These assignments are compared with SERS analyses of nucleotides and nucleosides.

引用

页码：359 / 364

页数：6

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