THE STRUCTURE OF AN INTERMEDIATE IN CLASS-II MHC MATURATION - CLIP BOUND TO HLA-DR3

被引：522

作者：

GHOSH, P

AMAYA, M

MELLINS, E

WILEY, DC

机构：

[1] HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138

[3] UNIV PENN,CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

[4] CHILDRENS SEASHORE HOUSE,PHILADELPHIA,PA 19104

来源：

NATURE | 1995年 / 378卷 / 6556期

关键词：

D O I：

10.1038/378457a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.

引用

页码：457 / 462

页数：6

共 50 条

[1]

Cresswell P.A., Rev. Immun., 12, pp. 259-293, (1994)

[2]

Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P., Nature, 360, pp. 474-477, (1992)

[3]

Sette A., Et al., Science, 258, pp. 1801-1804, (1992)

[4]

Mellins E., Et al., J. Exp. Med., 179, pp. 541-549, (1994)

[5]

Monji T., Mc Cormack A.L., Yates J.R., Pious D., J. Exp. Med., 153, pp. 4468-4477, (1994)

[6]

Avva R., Cresswell P., Immunity, 1, pp. 763-774, (1994)

[7]

Xu M., Capraro G.A., Daibata M., Reyes V.E., Humphreys R.E., Moiec. Immun., 31, pp. 723-731, (1994)

[8]

Frelsewinkel I.M., Schenck K., Koch N., Proc. Natn. Acad. Sei. U.S.A., 90, pp. 9703-9706, (1993)

[9]

Romagnoli P., Germain R.N., J. Exp. Med., 180, pp. 1107-1113, (1994)

[10]

Bljlmakers M.E., Benaroch P., Ploegh H.L., J. Exp. Med., 180, pp. 623-629, (1994)

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