CHEMOTHERAPY OF LARGE BOWEL CARCINOMA-FLUOROURACIL (FU) + HYDROXYUREA (HU) VS METHYL-CCNU, ONCOVIN, FLUOROURACIL, AND STREPTOZOTOCIN (MOF-STREP) - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY

被引：11

作者：

ENGSTROM, PF

MACINTYRE, JM

SCHUTT, AJ

DOUGLASS, HO

机构：

[1] MAYO CLIN & MAYO FDN, ROCHESTER, MN 55901 USA

[2] NEW YORK STATE DEPT HLTH, ROSWELL PK MEM INST, BUFFALO, NY 14263 USA

[3] DANA FARBER CANC INST, BOSTON, MA USA

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1985年 / 8卷 / 05期

关键词：

D O I：

10.1097/00000421-198510000-00004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this prospective randomized study of initial chemotherapy for advanced measurable metastatic large bowel carcinoma, the response rate was 6/32 (19%) for FU + HU and 5/32 (16%) for MOF-Strep; the estimated median survival is 43 weeks for both treatments. Patiens who received MOF-Strep experienced substantially greater vomiting and hematologic toxicity than patients who received FU + HU (p < 0.001).

引用

页码：358 / 361

页数：4

共 12 条

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[3]

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[8]

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THERAPY OF ADVANCED COLORECTAL CANCER WITH A COMBINATION OF 5-FLOUROURACIL, METHYL-1,3-CIS(2-CHLORETHYL)-1-NITROSOUREA, AND VINCRISTINE [J].

MOERTEL, CG ;

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JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1975, 54 (01) :69-71

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