IS SUSTAINED PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA RELEVANT TO THE DEVELOPMENT OF PUSTULAR PSORIASIS

被引：15

作者：

SAGAWA, Y

SHIOHARA, T

IMANISHI, K

NAGASHIMA, M

机构：

[1] KYORIN UNIV,SCH MED,DEPT DERMATOL,6-20-2 SHINKAWA,MITAKA,TOKYO 181,JAPAN

[2] TOKYO WOMENS MED COLL,DEPT MICROBIOL,TOKYO 162,JAPAN

来源：

DERMATOLOGY | 1993年 / 187卷 / 02期

关键词：

ADHESION MOLECULES; CYTOKINES; PUSTULAR PSORIASIS; TUMOR NECROSIS FACTOR-ALPHA;

D O I：

10.1159/000247210

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Tumor necrosis factor-alpha (TNF-alpha) has been implicated as one of the critical mediators of psoriasis. Evidence for an important role on the progression of the disease is increasing, while recent clinical studies have suggested its beneficial role in the disease. Based on the results of our sequential analysis of the serum cytokine levels in a patient with pustular psoriasis, we speculate that immunologic effects of constitutive local release of TNF-alpha may be quite different from those of its systemic injection.

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页码：81 / 83

页数：3

相关论文

共 17 条

[1]

BARKER JNWN, 1991, AM J PATHOL, V139, P869

[2]

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS [J].

BEVILACQUA, MP ;

STENGELIN, S ;

GIMBRONE, MA ;

SEED, B .

SCIENCE, 1989, 243 (4895) :1160-1165

[3]

RESPONSE TO TUMOR-NECROSIS-FACTOR IN 2 CASES OF PSORIASIS [J].

CREAVEN, PJ ;

STOLL, HL .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1991, 24 (05) :735-737

[4]

OVEREXPRESSION OF TRANSFORMING GROWTH FACTOR-ALPHA IN PSORIATIC EPIDERMIS [J].

ELDER, JT ;

FISHER, GJ ;

LINDQUIST, PB ;

BENNETT, GL ;

PITTELKOW, MR ;

COFFEY, RJ ;

ELLINGSWORTH, L ;

DERYNCK, R ;

VOORHEES, JJ .

SCIENCE, 1989, 243 (4892) :811-814

[5]

TOLERANCE TO TUMOR NECROSIS FACTOR IN RATS AND THE RELATIONSHIP TO ENDOTOXIN TOLERANCE AND TOXICITY [J].

FRAKER, DL ;

STOVROFF, MC ;

MERINO, MJ ;

NORTON, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (01) :95-105

[6]

STIMULATION OF THE ADHERENCE OF NEUTROPHILS TO UMBILICAL VEIN ENDOTHELIUM BY HUMAN RECOMBINANT TUMOR-NECROSIS-FACTOR [J].

GAMBLE, JR ;

HARLAN, JM ;

KLEBANOFF, SJ ;

VADAS, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8667-8671

[7]

INTERLEUKIN-1-ALPHA, TUMOR-NECROSIS-FACTOR-ALPHA, AND INTERFERON-GAMMA IN PSORIASIS [J].

GOMI, T ;

SHIOHARA, T ;

MUNAKATA, T ;

IMANISHI, K ;

NAGASHIMA, M .

ARCHIVES OF DERMATOLOGY, 1991, 127 (06) :827-830

[8]

KLEBANOFF SJ, 1986, J IMMUNOL, V136, P4220

[9]

A 2ND TUMOR-NECROSIS-FACTOR RECEPTOR GENE-PRODUCT CAN SHED A NATURALLY-OCCURRING TUMOR-NECROSIS-FACTOR INHIBITOR [J].

KOHNO, T ;

BREWER, MT ;

BAKER, SL ;

SCHWARTZ, PE ;

KING, MW ;

HALE, KK ;

SQUIRES, CH ;

THOMPSON, RC ;

VANNICE, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) :8331-8335

[10]

DETECTION OF CIRCULATING TUMOR NECROSIS FACTOR AFTER ENDOTOXIN ADMINISTRATION [J].

MICHIE, HR ;

MANOGUE, KR ;

SPRIGGS, DR ;

REVHAUG, A ;

ODWYER, S ;

DINARELLO, CA ;

CERAMI, A ;

WOLFF, SM ;

WILMORE, DW .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (23) :1481-1486