NEW SPECIES-SPECIFIC ALLELES AT THE PRIMATE MHC-G LOCUS

被引:11
作者
CORELL, A
MORALES, P
MARTINEZLASO, J
MARTINVILLA, JM
VARELA, P
PAZARTAL, E
ALLENDE, LM
RODRIGUEZ, C
ARNAIZVILLENA, A
机构
[1] Department of Immunology, 12th of October University Hospital, Complutense University of Madrid, Madrid
关键词
D O I
10.1016/0198-8859(94)90084-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Six different ape MHC-G DNA sequences (four in humans: HLA-G*01011, HLA-G*II, HLA-G*0103, and HLA-G*IV; one in chimpanzees: Patr-G*I; and one in gorillas: Gogo-G*I) have been obtained. Only synonymous or conservative (''Thr''-to-''Ser'') substitutions are allowed between the four human alleles. One allele of MHC-G exon-2 sequences has been found both in gorilla (Gorilla gorilla) and chimpanzee (Pan troglodytes). The Patr-G*I DNA sequence shows two nonsynonymous substitutions when compared with the human HLA-G*01011 sequence: ''CGG''-to-''TGG'' (''Arg''-to-''Trp'') at codon 35 and ''ATG''-to-''ATA'' (''Met''-to''Ile'') at codon 76. One nonsynonymous ''GAG''-to''GGG'' (''Glu''-to-''Gly'') substitution is observed in the Gogo-G*I exon-2 DNA sequence, when compared with the human *01011 allele. None of these three different substitutions have been observed in humans and ate, thus, considered species specific. Also, evidence is provided that the human HLA-G*II and G*0103 may have been originated after human speciation. Finally, phylogenetic relationships among the six MHC-G alleles, tamarins G-''like'' alleles, and other human class I genes (both ''classical'' and ''nonclassic'') are discussed.
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页码:52 / 55
页数:4
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