Six different ape MHC-G DNA sequences (four in humans: HLA-G*01011, HLA-G*II, HLA-G*0103, and HLA-G*IV; one in chimpanzees: Patr-G*I; and one in gorillas: Gogo-G*I) have been obtained. Only synonymous or conservative (''Thr''-to-''Ser'') substitutions are allowed between the four human alleles. One allele of MHC-G exon-2 sequences has been found both in gorilla (Gorilla gorilla) and chimpanzee (Pan troglodytes). The Patr-G*I DNA sequence shows two nonsynonymous substitutions when compared with the human HLA-G*01011 sequence: ''CGG''-to-''TGG'' (''Arg''-to-''Trp'') at codon 35 and ''ATG''-to-''ATA'' (''Met''-to''Ile'') at codon 76. One nonsynonymous ''GAG''-to''GGG'' (''Glu''-to-''Gly'') substitution is observed in the Gogo-G*I exon-2 DNA sequence, when compared with the human *01011 allele. None of these three different substitutions have been observed in humans and ate, thus, considered species specific. Also, evidence is provided that the human HLA-G*II and G*0103 may have been originated after human speciation. Finally, phylogenetic relationships among the six MHC-G alleles, tamarins G-''like'' alleles, and other human class I genes (both ''classical'' and ''nonclassic'') are discussed.