STRUCTURAL RELATIONSHIP BETWEEN THE VANCOMYCIN RESISTANCE PROTEIN VANH AND 2-HYDROXYCARBOXYLIC ACID DEHYDROGENASES

被引：85

作者：

ARTHUR, M

MOLINAS, C

DUTKAMALEN, S

COURVALIN, P

机构：

[1] Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, 28, rue du Dr. Roux

来源：

GENE | 1991年 / 103卷 / 01期

关键词：

D-ALANINE; D-ALANINE LIGASE; ENTEROCOCCUS; CELL WALL; GLYCOPEPTIDE RESISTANCE; PEPTIDOGLYCAN SYNTHESIS;

D O I：

10.1016/0378-1119(91)90405-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

引用

页码：133 / 134

页数：2

共 12 条

[1] BIRKTOFT JJ, 1983, J BIOL CHEM, V258, P472
[2] IDENTIFICATION OF VANCOMYCIN RESISTANCE PROTEIN VANA AS A D-ALANINE - D-ALANINE LIGASE OF ALTERED SUBSTRATE-SPECIFICITY
BUGG, TDH
DUTKAMALEN, S
ARTHUR, M
COURVALIN, P
WALSH, CT
[J]. BIOCHEMISTRY, 1991, 30 (08) : 2017 - 2021
[3] THE VANA GLYCOPEPTIDE RESISTANCE PROTEIN IS RELATED TO D-ALANYL-D-ALANINE LIGASE CELL-WALL BIOSYNTHESIS ENZYMES
DUTKAMALEN, S
MOLINAS, C
ARTHUR, M
COURVALIN, P
[J]. MOLECULAR AND GENERAL GENETICS, 1990, 224 (03): : 364 - 372
[4] Gale EF, 1981, MOL BASIS ANTIBIOTIC
[5] CLONING, SEQUENCING AND EXPRESSION IN ESCHERICHIA-COLI OF THE D-2-HYDROXYISOCAPROATE DEHYDROGENASE GENE OF LACTOBACILLUS-CASEI
LERCH, HP
BLOCKER, H
KALLWASS, H
HOPPE, J
TSAI, H
COLLINS, J
[J]. GENE, 1989, 78 (01) : 47 - 57
[6] RAPID METHOD FOR DETERMINING SEQUENCES IN DNA BY PRIMED SYNTHESIS WITH DNA-POLYMERASE
SANGER, F
COULSON, AR
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1975, 94 (03) : 441 - +
[7] DIVERGENT TRANSCRIPTION OF PDXB AND HOMOLOGY BETWEEN THE PDXB AND SERA GENE-PRODUCTS IN ESCHERICHIA-COLI K-12
SCHOENLEIN, PV
ROA, BB
WINKLER, ME
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (11) : 6084 - 6092
[8] REDESIGN OF THE COENZYME SPECIFICITY OF A DEHYDROGENASE BY PROTEIN ENGINEERING
SCRUTTON, NS
BERRY, A
PERHAM, RN
[J]. NATURE, 1990, 343 (6253) : 38 - 43
[9] STRUCTURE OF VANCOMYCIN AND ITS COMPLEX WITH ACETYL-D-ALANYL-D-ALANINE
SHELDRICK, GM
JONES, PG
KENNARD, O
WILLIAMS, DH
SMITH, GA
[J]. NATURE, 1978, 271 (5642) : 223 - 225
[10] TOBEY KL, 1986, J BIOL CHEM, V261, P2179

← 1 2 →