FURTHER-STUDIES ON THE ACTIONS OF ENDOTHELIN-1 ON BLOOD-FLOW IN HUMAN SKIN

被引:22
作者
BUNKER, CB
COULSON, ML
HAYES, NA
DOWD, PM
FOREMAN, JC
机构
[1] UNIV LONDON UNIV COLL, UNIV COLL & MIDDLESEX SCH MED, DEPT PHARMACOL, GOWER ST, LONDON WC1E 6BT, ENGLAND
[2] UNIV LONDON UNIV COLL, UNIV COLL & MIDDLESEX SCH MED, DEPT DERMATOL, LONDON WC1E 6BT, ENGLAND
关键词
D O I
10.1111/j.1365-2133.1992.tb08037.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
When injected into human skin, endothelin-1 produces intense vasoconstriction localized to the site of the injection, but this area of vasoconstriction is surrounded by vasodilatation which spreads several centimetres from the injection site. The vasodilatation induced by intradermal injection of endothelin-1 (63 pmol) into human skin is prevented by local anaesthetic. Pretreatment of human skin with capsaicin also inhibits this response. Pretreatment of subjects with the selective histamine H1-receptor antagonist cetirizine, 10 mg orally 4 h before intradermal injections, inhibited vasodilatation caused by the intradermal injection of histamine (750 pmol), endothelin-1 (63 pmol), and carbachol (750 pmol). Endothelin-1 (0.3-10-mu-m) and carbachol (1-30-mu-m) failed to induce histamine release from rat peritoneal mast cells. We conclude that the vasodilatation caused by intradermal injection of endothelin-1 into human skin is neurogenic and is probably mediated by neuropeptide-containing primary afferent neurones. Because neither carbachol nor endothelin-1 cause histamine release from mast cells, our data suggest that histamine release from mast cells at the effector end of the axon reflex is responsible for the carbachol- and endothelin-induced vasodilatation in human skin.
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页码:85 / 90
页数:6
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