LIPOXYGENASE-MEDIATED SECRETORY EFFECT OF CANATOXIN, THE TOXIC PROTEIN FROM CANAVALIA-ENSIFORMIS SEEDS

被引：42

作者：

BARJAFIDALGO, C ^{[1
]}

GUIMARAES, JA ^{[1
]}

CARLINI, CR ^{[1
]}

机构：

[1] UNIV ESTADO RIO DE JANEIRO,INST BIOL,DEPT PHARMACOL,RIO DE JANEIRO,BRAZIL

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90019-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Canatoxin was shown to induce serotonin release from rabbit platelets and rat brain synaptosomes, as well as to release insulin from isolated pancreatic islets. All these effects were dose-dependent and were inhibited by lipoxygenase inhibitors, such as nordihydroguaiaretic acid and esculetin, but not by indomethacin, a cyclo-oxygenase inhibitor. The data suggest that canatoxin-induced secretory effect results from the activation of the lipoxygenase pathway which would elicit exocytosis. Thus, canatoxin might be a useful tool for the study of biological events that involve lipoxygenase mediation.

引用

页码：453 / 459

页数：7

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