HOW ARE THE REGULATORS REGULATED

被引：39

作者：

FALVEY, E

SCHIBLER, U

机构：

[1] Department of Molecular Biology, University of Geneva

来源：

FASEB JOURNAL | 1991年 / 5卷 / 03期

关键词：

TRANSCRIPTION FACTOR; REGULATORY GENE; HOMEODOMAIN; DIFFERENTIAL SPLICING; PHOSPHORYLATION; DIMERIZATION;

D O I：

10.1096/fasebj.5.3.2001790

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell-type-specific expression of many genes is determined at the level of transcription. Transcription factors, acting as promoter and enhancer elements, are involved in the control of this process. To understand the basis of this regulation it has become important to analyze the control of transcription factors themselves. A variety of transcriptional, translational, and posttranslational mechanisms have been described, and are discussed in this review article.

引用

收藏

页码：309 / 314

页数：6

相关论文

共 51 条

[1] Homeodomain proteins and the regulation of gene expression [J].

Affolter, M. ;

Schier, A. ;

Gehring, W. J. .

CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) :485-495

[2] ACTIVATION OF DNA-BINDING ACTIVITY IN AN APPARENTLY CYTOPLASMIC PRECURSOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR [J].

BAEUERLE, PA ;

BALTIMORE, D .

CELL, 1988, 53 (02) :211-217

[3]

BAEUERLE PA, 1990, IN PRESS MOL ASPECTS

[4] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[5] EXTINCTION OF IG GENES EXPRESSION IN MYELOMA X FIBROBLAST SOMATIC-CELL HYBRIDS IS ACCOMPANIED BY REPRESSION OF THE OCT-2 GENE ENCODING A B-CELL SPECIFIC TRANSCRIPTION FACTOR [J].

BERGMAN, Y ;

STRICH, B ;

SHARIR, H ;

BER, R ;

LASKOV, R .

EMBO JOURNAL, 1990, 9 (03) :849-855

[6] THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-GHF-1 IS A HOMEOBOX-CONTAINING PROTEIN [J].

BODNER, M ;

CASTRILLO, JL ;

THEILL, LE ;

DEERINCK, T ;

ELLISMAN, M ;

KARIN, M .

CELL, 1988, 55 (03) :505-518

[7] BIOCHEMICAL-ANALYSIS OF TRANSCRIPTIONAL ACTIVATION BY JUN - DIFFERENTIAL ACTIVITY OF C-JUN AND V-JUN [J].

BOHMANN, D ;

TJIAN, R .

CELL, 1989, 59 (04) :709-717

[8] A CYCLIC-AMP RESPONSE ELEMENT MEDIATES REPRESSION OF TYROSINE AMINOTRANSFERASE GENE-TRANSCRIPTION BY THE TISSUE-SPECIFIC EXTINGUISHER LOCUS TSE-1 [J].

BOSHART, M ;

WEIH, F ;

SCHMIDT, A ;

FOURNIER, REK ;

SCHUTZ, G .

CELL, 1990, 61 (05) :905-916

[9] AUTOREGULATION OF PIT-1 GENE-EXPRESSION MEDIATED BY 2 CIS-ACTIVE PROMOTER ELEMENTS [J].

CHEN, RP ;

INGRAHAM, HA ;

TREACY, MN ;

ALBERT, VR ;

WILSON, L ;

ROSENFELD, MG .

NATURE, 1990, 346 (6284) :583-586

[10] THE B-CELL-SPECIFIC OCT-2 PROTEIN CONTAINS POU BOX-TYPE AND HOMEO BOX-TYPE DOMAINS [J].

CLERC, RG ;

CORCORAN, LM ;

LEBOWITZ, JH ;

BALTIMORE, D ;

SHARP, PA .

GENES & DEVELOPMENT, 1988, 2 (12A) :1570-1581

← 1 2 3 4 5 6 →