STUDIES ON UPSCALING PARAMETERS OF THE GRAL HIGH SHEAR GRANULATION PROCESS

被引：49

作者：

HORSTHUIS, GJB ^{[1
]}

VANLAARHOVEN, JAH ^{[1
]}

VANROOIJ, RCBM ^{[1
]}

VROMANS, H ^{[1
]}

机构：

[1] ORGANON INT BV,DEPT TECHNOL,POB 20,5340 BH OSS,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 92卷 / 1-3期

关键词：

UPSCALING; HIGH SHEAR MIXER; GRAL; WET GRANULATION; FROUDE-NUMBER;

D O I：

10.1016/0378-5173(93)90273-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Granulation of lactose in three high shear mixers of the type Gral (Gral 10, 75 and 300) is compared. An attempt is made to identify scale-up parameters. It is concluded that an equal Froude-number results in a comparable process concerning temperature and particle size distribution. A constant relative swept volume and a constant impellor tip speed appeared not to result in a comparable process. Monitoring the temperature rise during the process might be an interesting process control.

引用

页码：143 / 150

页数：8

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