NEW CYTOTOXIC DRUGS AND TARGETS IN ONCOLOGY

被引：4

作者：

BEIJNEN, JH

机构：

[1] Slotervaart Hospital/Netherlands Cancer Institute, EC Amsterdam, 1066

来源：

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION | 1992年 / 14卷 / 4A期

关键词：

BRYOSTATIN-1; NEW CYTOTOXIC DRUGS; SIGNAL TRANSDUCTION; TAXOL; TOPOISOMERASE INHIBITORS; TOPOTECAN; TUBULIN POISONS;

D O I：

10.1007/BF01962548

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New agents in the preclinical and early clinical pipeline (phases I and II) are described and some of the problems associated with their development are reviewed. The article focuses on tubulin poisons such as taxol, topoisomerase inhibitors, such as topotecan, and drugs such as bryostatin 1 and miltefosin, which interfere with specific signal transduction pathways involved in malignant cell growth.

引用

页码：258 / 267

页数：10

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