IDENTIFICATION OF A REGION OF A MURINE LEUKEMIA-VIRUS LONG TERMINAL REPEAT WITH NOVEL TRANSCRIPTIONAL REGULATORY ACTIVITIES

被引:21
作者
CHEN, HL [1 ]
YOSHIMURA, FK [1 ]
机构
[1] UNIV WASHINGTON, SCH MED, DEPT BIOL STRUCT, SEATTLE, WA 98195 USA
关键词
D O I
10.1128/JVI.68.5.3308-3316.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The 93-bp region downstream of the enhancer (DEN) in the long terminal repeat (LTR) of the mink cell focus-forming virus (MCF13) has been shown to be important for transcriptional activation and viral lymphomagenicity (J. C. Tupper, H. Chen, E. F. Hays, G. C. Bristol, and F. K. Yoshimura, J. Virol. 66:7080-7088, 1992). In this report, we have further explored the role of the DEN region in transcriptional activation. We observed that it has enhancer-like abilities as well as some unique LTR properties. Transcriptional activation by the DEN region involved interactions with enhancer sequences that were either synergistic or additive, depending on the cell type. The most intriguing property of the DEN region is its ability to induce transcription in activated T cells. This activity is unique for the LTR in that no other LTR region can do this. We also examined the role of the DEN region in retroviral lymphomagenesis. We cloned and sequenced proviral LTRs integrated upstream of the cellular c-myc gene from DNA obtained from thymic tumors induced by DEN region deletion mutant viruses in AKR mice. We determined that for transcriptional activation of the c-myc proto-oncogene, enhancer sequences can substitute for the DEN region. This study identifies the significance of non-enhancer sequences in the LTR for the oncogenesis of the MCF13 retrovirus.
引用
收藏
页码:3308 / 3316
页数:9
相关论文
共 65 条
  • [1] TRANSCRIPTIONALLY ACTIVE DNA REGION THAT REARRANGES FREQUENTLY IN MURINE LYMPHOID TUMORS
    ADAMS, JM
    GERONDAKIS, S
    WEBB, E
    MITCHELL, J
    BERNARD, O
    CORY, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (22): : 6966 - 6970
  • [2] PROTEIN KINASE-C AND T-CELL ACTIVATION
    BERRY, N
    NISHIZUKA, Y
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 189 (02): : 205 - 214
  • [3] IDENTIFICATION OF THE SL3-3 VIRUS ENHANCER CORE AS A T-LYMPHOMA CELL-SPECIFIC ELEMENT
    BORAL, AL
    OKENQUIST, SA
    LENZ, J
    [J]. JOURNAL OF VIROLOGY, 1989, 63 (01) : 76 - 84
  • [4] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
  • [5] A 3' END FRAGMENT ENCOMPASSING THE TRANSCRIPTIONAL ENHANCERS OF NONDEFECTIVE FRIEND-VIRUS CONFERS ERYTHROLEUKEMOGENICITY ON MOLONEY LEUKEMIA-VIRUS
    CHATIS, PA
    HOLLAND, CA
    SILVER, JE
    FREDERICKSON, TN
    HOPKINS, N
    HARTLEY, JW
    [J]. JOURNAL OF VIROLOGY, 1984, 52 (01) : 248 - 254
  • [6] ROLE FOR THE 3' END OF THE GENOME IN DETERMINING DISEASE SPECIFICITY OF FRIEND AND MOLONEY MURINE LEUKEMIA VIRUSES
    CHATIS, PA
    HOLLAND, CA
    HARTLEY, JW
    ROWE, WP
    HOPKINS, N
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14): : 4408 - 4411
  • [7] LYMPHOMAGENICITY OF RECOMBINANT MINK CELL FOCUS-INDUCING MURINE LEUKEMIA VIRUSES
    CLOYD, MW
    HARTLEY, JW
    ROWE, WP
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 151 (03) : 542 - 552
  • [8] MURINE T-LYMPHOMAS IN WHICH THE CELLULAR MYC ONCOGENE HAS BEEN ACTIVATED BY RETROVIRAL INSERTION
    CORCORAN, LM
    ADAMS, JM
    DUNN, AR
    CORY, S
    [J]. CELL, 1984, 37 (01) : 113 - 122
  • [9] CONTINGENT GENETIC REGULATORY EVENTS IN LYMPHOCYTE-T ACTIVATION
    CRABTREE, GR
    [J]. SCIENCE, 1989, 243 (4889) : 355 - 361
  • [10] CUYPERS HT, 1984, CELL, V37, P141