AN ALPHA/BETA-BARREL FULL OF EVOLUTIONARY TROUBLE

被引：92

作者：

FARBER, GK

机构：

[1] PENN STATE UNIV, DEPT MOLEC & CELL BIOL, UNIV PK, PA 16802 USA

[2] PENN STATE UNIV, CTR BIOMOLEC STRUCT & FUNC, UNIV PK, PA 16802 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(05)80114-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eight-stranded alpha/beta-barrel (TIM barrel) is by far the most common shape for an enzyme: roughly one out of 10 enzymes have this domain. Three different evolutionary pathways have been proposed for this group of proteins. Recent work still cannot differentiate between the proposed pathways.

引用

页码：409 / 412

页数：4

共 45 条

[1] EFFECTS OF THE PHENYLALANINE-22-]LEUCINE, GLUTAMIC ACID-49-]METHIONINE, GLYCINE-234-]ASPARTIC ACID, AND GLYCINE-234-]LYSINE MUTATIONS ON THE FOLDING AND STABILITY OF THE ALPHA-SUBUNIT OF TRYPTOPHAN SYNTHASE FROM ESCHERICHIA-COLI
BEASTY, AM
HURLE, MR
MANZ, JT
STACKHOUSE, T
ONUFFER, JJ
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1986, 25 (10) : 2965 - 2974
[2] BELLAMY HD, 1989, J BIOL CHEM, V264, P11887
[3] SOLUTION OF THE STRUCTURE OF ASPERGILLUS-NIGER ACID ALPHA-AMYLASE BY COMBINED MOLECULAR REPLACEMENT AND MULTIPLE ISOMORPHOUS REPLACEMENT METHODS
BRADY, RL
BRZOZOWSKI, AM
DEREWENDA, ZS
DODSON, EJ
DODSON, GG
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1991, 47 : 527 - 535
[4] ROLE OF DIFFUSION IN THE FOLDING OF THE ALPHA-SUBUNIT OF TRYPTOPHAN SYNTHASE FROM ESCHERICHIA-COLI
CHRUNYK, BA
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1990, 29 (08) : 2149 - 2154
[5] MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING-OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
COLLYER, CA
HENRICK, K
BLOW, DM
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 212 (01) : 211 - 235
[6] PREDICTION OF SECONDARY STRUCTURE BY EVOLUTIONARY COMPARISON - APPLICATION TO THE ALPHA-SUBUNIT OF TRYPTOPHAN SYNTHASE
CRAWFORD, IP
NIERMANN, T
KIRSCHNER, K
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1987, 2 (02): : 118 - 129
[7] CURMI PMG, 1992, J BIOL CHEM, V267, P16980
[8] PROTEIN ENGINEERING OF A DISULFIDE BOND IN A BETA/ALPHA-BARREL PROTEIN
EDER, J
WILMANNS, M
[J]. BIOCHEMISTRY, 1992, 31 (18) : 4437 - 4444
[9] STABLE SUBSTRUCTURES OF EIGHTFOLD BETA-ALPHA-BARREL PROTEINS - FRAGMENT COMPLEMENTATION OF PHOSPHORIBOSYLANTHRANILATE ISOMERASE
EDER, J
KIRSCHNER, K
[J]. BIOCHEMISTRY, 1992, 31 (14) : 3617 - 3625
[10] THE EVOLUTION OF ALPHA-BETA-BARREL ENZYMES
FARBER, GK
PETSKO, GA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (06) : 228 - &

← 1 2 3 4 5 →