EFFECTS OF DOPAMINE ANTAGONISTS ON RETINAL B-WAVE RECOVERY AFTER RETINAL ISCHEMIA

被引：23

作者：

CHIOU, GCY

LI, BHP

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University College ofMedicine, College Station, Texas

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1993年 / 9卷 / 02期

关键词：

D O I：

10.1089/jop.1993.9.179

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Retinal ischemia was developed by occlusion of the central retinal artery for 30 minutes. The artery was reperfused thereafter, and the recovery of the b-wave amplitude was determined as an indication of the recovery of retinal function after ischemia. Following ischemia, it was found that dopamine antagonists, including chlofluperol, metoclopramide, trifluperol and droperidol, increased in b-wave amplitude recovery significantly over the control b-wave recovery. Similar effects were observed with haloperidol and loxapine, but to a lesser extent. The results correlated well with the improvement of retinal blood flow by these dopamine antagonists (4,5). Neither floropipamide, a dopamine antagonist, nor bromocriptine, a dopamine agonist, affected the b-wave recovery after ischemia. These results also correlate well with the inability of these agents to increase the retinal blood flow measured by the microsphere technique (4,5). These findings suggest that most of the dopamine antagonists, with the exception of floropipamide, could be used for the treatment and/or prevention of ischemic retinopathy.

引用

页码：179 / 185

页数：7

共 6 条

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[2]

U.S. Department of Health and Human Services, (1983)

[3]

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[4]

Chiou G.C.Y., Chen Y.J., Effects of dopamine agonist, bromocriptine, and some dopamine antagonists on ocular blood flow, J. Ocular Pharmacol., 8, pp. 285-294, (1992)

[5]

Chiou G.C.Y., Chen Y.J., Improvement of ocular blood flow with dopamine antagonists on ocular hypertensive rabbit eyes, Acta Pharmacol. Sinica, 13, pp. 481-484, (1992)

[6]

Crosson C.E., Willis J.A., Potter D.E., Effect of the calcium antagonist, nifedipine, on the ischemic retinal dysfunction, J. Ocular Pharmacol., 6, pp. 293-299, (1990)

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