RA-III LACTONE, A 19-MEMBERED RING ANALOG OF RAS, ANTITUMOR CYCLIC HEXAPEPTIDE

被引：7

作者：

HITOTSUYANAGI, Y ^{[1
]}

KONDO, K ^{[1
]}

TAKEYA, K ^{[1
]}

ITOKAWA, H ^{[1
]}

机构：

[1] TOKYO COLL PHARM,DEPT PHARMACOGNOSY,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 14期

关键词：

CYCLIC HEXAPEPTIDE; N-]O ACYL REARRANGEMENT; CONFORMATION ANALYSIS; ANTITUMOR ACTIVITY;

D O I：

10.1016/S0040-4039(00)76793-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Antitumor cyclic hexapeptide RA-III (2) has been converted to a lactone analogue 3 which is the first analogue of RAs in which the 18-membered macro ring was modified. 3 was found to possess promising antitumor activity, and its solution conformation was established by NMR spectroscopy.

引用

页码：2191 / 2194

页数：4

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