THIOUREA ANALOGS OF RESINIFERATOXIN AS LIGANDS FOR THE VANILLOID RECEPTOR

被引：9

作者：

LEE, JW

ACS, G

BLUMBERG, PM

MARQUEZ, VE

机构：

[1] NCI,DIV CANC TREATMENT,MED CHEM LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

[2] NCI,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,MOLEC MECH TUMOR PROMOT SECT,BETHESDA,MD 20892

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 13期

关键词：

D O I：

10.1016/0960-894X(95)00217-H

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A thiourea bridge was tested as a linker to replace the OC(O)CH2 ester group that connects resiniferonol-9,13,14-orthophenylacetate to the 3-methoxy-4-hydroxyphenyl moiety in resiniferatoxin (RTX). The resulting compounds showed lower affinity for the vanilloid receptor than did the parent RTX.

引用

页码：1331 / 1334

页数：4

共 17 条

[1] STRUCTURE-ACTIVITY RELATIONS OF POLYFUNCTIONAL DITERPENES OF THE DAPHNANE TYPE .1. REVISED STRUCTURE FOR RESINIFERATOXIN AND STRUCTURE-ACTIVITY RELATIONS OF RESINIFERONOL AND SOME OF ITS ESTERS [J].