STUDIES ON THE HOMING OF MYCOBACTERIUM-SENSITIZED LYMPHOCYTES-T TO THE SYNOVIUM DURING PASSIVE ADJUVANT ARTHRITIS

被引：18

作者：

DEJOY, SQ

FERGUSONCHANOWITZ, K

ORONSKY, AL

ZABRISKIE, JB

KERWAR, SS

机构：

[1] AMER CYANAMID CO, LEDERLE LABS, DIV MED RES, ONCOL & IMMUNOL RES SECT, PEARL RIVER, NY 10965 USA

[2] ROCKEFELLER UNIV, NEW YORK, NY 10021 USA

来源：

CELLULAR IMMUNOLOGY | 1990年 / 130卷 / 01期

关键词：

D O I：

10.1016/0008-8749(90)90173-O

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The migration of intravenously administered adjuvant sensitized T lymphocytes to the knee synovium of recipient rats undergoing passive adjuvant arthritis has been followed. Using fluorescein isothiocyanate (FITC)-labeled adjuvant-sensitized T cells and anticollagen IgG, the present studies demonstrate the presence of fluorescent cells in the inflamed knee synovium of recipient rats undergoing passive arthritis. Proliferation studies indicate that synovial cells from these rats respond to Mycobacterium tuberculosis (MT). Since cross-reactivity between Mycobacterial antigens and cartilage proteoglycans has been previously demonstrated, it is suggested that adjuvant-sensitized T cells that are injected into naive rats migrate to the synovium, proliferate in response to cartilage proteoglycan, and initiate passive arthritis. © 1990.

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页码：195 / 203

页数：9

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