FACTORS INFLUENCING BIRTH-WEIGHT IN NEWBORNS OF DIABETIC AND NONDIABETIC WOMEN A POPULATION BASED STUDY

被引：10

作者：

FRASER, D

WEITZMAN, S

LEIBERMAN, JR

ESCHWEGE, E

机构：

[1] Epidemiology and Health Services Evaluation Unit, Ben-Gurion University of the Negev, Beersheva, 84105

[2] Department of Gynecology and Obstetrics B, 'Soroka' Medical Center and Faculty for Health Sciences, Ben-Gurion University of the Negev, Beersheva, 84105

[3] INSERM, Paris

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1990年 / 6卷 / 04期

关键词：

INFANTS; BIRTH WEIGHT; MATERNAL DIABETES; GLYCOSYLATED HEMOGLOBIN;

D O I：

10.1007/BF00151720

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Maternal diabetes is known to be related to an increase in birth weight of the offspring. However, the mechanism of the association is not entirely clear. In addition, the contribution of the demographic, obstetric and metabolic factors to birth weight in diabetic mothers is not well defined. All the diabetic women (68 requiring insulin-treatment and 403 on diet alone) and a random sample of 1 in 12 of all non-diabetic women (893 women) who delivered in one regional hospital between March 1987 and June 1988 inclusive, were included in the study. Tests for gestational diabetes are routinely performed in our pregnant women population, thus, the study is a population based one. The mean birth weight of infants of diabetic mothers adjusted for gestational age was higher than in those of non-diabetic mothers. However, no relationship was found between maternal glycosylated hemoglobin measured at delivery and the infants birth weight. Furthermore, at each week of gestation, infants born to diabetic mothers were heavier than the infants of non-diabetic mothers (for weeks 37 to 40, p < 0.05), while no differences were found in glycosylated hemoglobin levels between the two groups at any time. In a multivariate model we showed that after controlling for gestational age, the only factors which independently and significantly affected birth weight in our population were diabetes, ethnic origin, and the parity of the mother. Our findings support the possibility that substances which induce hyperinsulinemia, other than glucose, may be related to the higher birth weight of infants of diabetic mothers.

引用

页码：427 / 431

页数：5

共 11 条

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