TOTAL SYNTHESES OF THE DITERPENOIDS (-)-KOLAVENOL AND (-)-AGELASINE-B

被引：51

作者：

PIERS, E

ROBERGE, JY

机构：

[1] Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 46期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(00)60896-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trans-clerodane diterpenoids (-)-kolavenol (2) and (-)-agelasine B (1) have been prepared from the enantiomerically pure decalone 3. The key steps of the syntheses involve the stereoselective alkylation of the nitrile 4 (to give 5), the efficient coupling of the iodides 10 and 11 to produce the clerodane skeleton 12, and the electrochemical reduction of 16 to provide (-)-1.

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页码：6923 / 6926

页数：4

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