POTENTIAL THERAPEUTIC INITIATIVES FOR FIBROGENIC LUNG-DISEASES

被引：34

作者：

GOLDSTEIN, RH

FINE, A

机构：

[1] BOSTON UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02118

[2] VET ADM MED CTR,BOSTON,MA

来源：

CHEST | 1995年 / 108卷 / 03期

关键词：

ANTIOXIDANTS; GROWTH FACTORS; PULMONARY FIBROSIS; TYPE I COLLAGEN;

D O I：

10.1378/chest.108.3.848

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Fibrotic process affecting the lung and other tissues is characterized by stimulation of fibroblast proliferation and connective tissue deposition. Conventional therapy consisting of glucocorticoids or cytotoxic agents is usually ineffective in blocking progression of disease, Potential new therapies have emerged from the use of animal models of pulmonary fibrosis and recent advances in the cellular and molecular biology of inflammatory reactions, Such therapies involve the use of substances directed against the action of certain growth factors, cytokines, or oxidants that are elaborated during the fibrotic reaction. In this article, we review possible therapeutic applications of these advances.

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页码：848 / 855

页数：8

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