DETERMINATION OF CIPROFLOXACIN BY DIFFERENTIAL PULSE POLAROGRAPHY

被引：32

作者：

ODEA, P

GARCIA, AC

ORDIERES, AJM

BLANCO, PT

SMYTH, MR

机构：

[1] UNIV OVIEDO,DEPT PHYS & ANALYT CHEM,ASTURIAS,SPAIN

[2] DUBLIN CITY UNIV,SCH CHEM SCI,DUBLIN 9,IRELAND

来源：

ELECTROANALYSIS | 1990年 / 2卷 / 08期

关键词：

D O I：

10.1002/elan.1140020811

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and rapid method for the determination of the antibiotic ciprofloxacin by differential pulse polarography (DPP) has been developed. The changes in the voltammetric behavior of this drug compound with pH was studied, and the most suitable pH for analytical purposes was found to be pH 8.5. The DPP behavior of this compound at this pH exhibited two reduction waves at −1.44 and −1.64 V. The former wave could be used to determine ciprofloxacin between 5 × 10−7 and 3 × 10−5 M. The method was applied to the determination of ciprofloxacin in formulated tablets with a relative standard deviation of less than 0.4%. Copyright © 1990 VCH Publishers, Inc.

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页码：637 / 641

页数：5

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