CANDIDA-ALBICANS HSP-90 - LINK BETWEEN PROTECTIVE AND AUTO IMMUNITY

被引：27

作者：

MATTHEWS, RC

机构：

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1992年 / 36卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1099/00222615-36-6-367

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Heat shock proteins (HSP) are thought to play a role in the aetiology of autoimmune diseases, but are also common targets for the immune response to many infections. Patients recovering from systemic candidosis produce antibodies to Candida albicans HSP 90, both to species-specific epitopes and, more commonly, to epitopes shared with human HSP 90. One such autoreactive antibody was protective in a mouse model of systemic candidosis.

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页码：367 / 370

页数：4

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