THE PROGNOSTIC-SIGNIFICANCE OF DNA PLOIDY FOR NEUROBLASTOMA

被引：3

作者：

NAKAZAWA, M

机构：

[1] The Second Department of Surgery, Mie University School of Medicine, Tsu, 514

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 03期

关键词：

NEUROBLASTOMA; DNA FLOW CYTOMETRY; DNA PLOIDY;

D O I：

10.1007/BF00309230

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Flow cytometric DNA analysis was performed on 45 neuroblastomas in order to evaluate the prognostic significance of DNA ploidy. The DNA ploidy was diploid in 14 and aneuploid in 31 neuroblastomas and did not correlate with the conventional prognostic variables such as age, Evans' stage, or the primary site of the tumor. The survival of 31 patients with aneuploid tumors was comparable to that of 14 patients with diploid tumors. On the other hand, DNA aneuploidy was associated with a decreased long-term survival in 21 patients older than 24 months of age at the time of operation, and in 27 patients with advanced disease at Evans' stage III or IV. These results suggest that more intensive and longer-term postoperative chemotherapy is necessary for neuroblastoma patients older than 24 months of age, or for those with advanced disease if they have aneuploid tumors.

引用

页码：215 / 219

页数：5

共 17 条

[1]

Laerum O.D., Farsund T., Clinical application of flow cytometry: A review, Cytometry, 2, pp. 1-13, (1981)

[2]

Barlogie B., Raber M.N., Schumann J., Johnson T.S., Drewinko B., Swartzendruber D.E., Gohde W., Andreeff M., Freireich E.J., Flow cytometry in clinical cancer research, Cancer Res, 43, pp. 3982-3997, (1983)

[3]

Merkel D.E., McGuire W.L., Ploidy, proliferative activity and prognosis: DNA flow cytometry of solid tumors, Cancer, 65, pp. 1194-1205, (1990)

[4]

Look A.T., Hayes F.A., Nitschke R., McWillia N.B., Green A.A., Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma, N Engl J Med, 311, pp. 231-235, (1984)

[5]

Gansler T., Chatten J., Varello M., Bunin G.R., Atkinson B., Flow cytometric DNA analysis of neuroblastoma: Correlation with histology and clinical outcome, Cancer, 58, pp. 2453-2458, (1986)

[6]

Brenner D.W., Barranco S.C., Winslow B.H., Shaeffer J., Flow cytometric analysis of DNA content in children with neuroblastoma, J Pediatr Surg, 24, pp. 204-207, (1989)

[7]

Evans A.E., D'Angio G.J., Randolph J.A., A proposed staging for children with neuroblastoma, Cancer, 27, pp. 347-348, (1971)

[8]

Schutte B., Reynders M.M.J., Bosman F.T., Blijham G.H., Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue, Cytometry, 6, pp. 26-30, (1985)

[9]

Vindelov L.L., Christensen I.J., Nissen N.I., A detergent trypsin method for the preparation of nuclei for flow cytometric DNA analysis, Cytometry, 3, pp. 323-327, (1983)

[10]

Breslow N., McCann B., Statistical estimation of prognosis for children with neuroblastoma, Cancer Res, 31, pp. 2098-2103, (1971)

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