ANTICOAGULATION AND HEMOSTASIS IN CARDIAC SURGICAL PATIENTS

被引：4

作者：

KONDO, NI ^{[1
]}

MADDI, R ^{[1
]}

EWENSTEIN, BM ^{[1
]}

GOLDHABER, SZ ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,DIV CARDIOVASC,75 FRANCIS ST,BOSTON,MA 02115

来源：

JOURNAL OF CARDIAC SURGERY | 1994年 / 9卷 / 04期

关键词：

D O I：

10.1111/j.1540-8191.1994.tb00875.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Optimizing anticoagulation and hemostasis during cardiopulmonary bypass and perioperatively helps to ensure the best possible clinical outcome. This article reviews the pharmacology of unfractionated and low-molecular weight heparin, aprotinin, desmopressin, dextran, antiplatelet agents, warfarin, and direct thrombin inhibitors. Their use is discussed in the context of coronary artery surgery, valvular surgery, and mechanical cardiac support devices, as well as in the management of acute ischemic syndromes, atrial fibrillation, and prevention and treatment of venous thromboembolism. Progress in the development and utilization of these anticoagulants and antiplatelet agents has supported the major advances that have been achieved in cardiac surgery.

引用

页码：443 / 461

页数：19