P-GLYCOPROTEIN IN ADULT SOLID TUMORS - EXPRESSION AND PROGNOSTIC-SIGNIFICANCE

被引：58

作者：

LEIGHTON, JC ^{[1
]}

GOLDSTEIN, LJ ^{[1
]}

机构：

[1] FOX CHASE CANC CTR, PHILADELPHIA, PA 19111 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1995年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0889-8588(18)30095-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several potential mechanisms of chemotherapy resistance have been identified in adult solid tumors. The multidrug resistance (MDR) phenotype is one mechanism by which tumors may simultaneously develop resistance to multiple chemotherapeutic agents and is associated with P-glycoprotein expression. Ln this article, the authors examine the literature and summarize the various techniques used to measure MDR1 gene expression, patterns of expression in adult solid tumors.

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页码：251 / 273

页数：23

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