MYOSIN MOTOR FUNCTION - STRUCTURAL AND MUTAGENIC APPROACHES

被引：18

作者：

RUPPEL, KM

SPUDICH, JA

机构：

[1] K.M. Ruppel and J.A. Spudich, B405 Beckman Center, Department of Biochemistry, Stanford

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 01期

关键词：

D O I：

10.1016/0955-0674(95)80049-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances in three areas of myosin research - structural biology, in vitro motility assays, and mutagenesis - are leading to a new understanding of the molecular mechanism of chemomechanical transduction by this motor protein. Highlights include rational design of mutants using the crystal structure of subfragment 1, combined in vivo and in vitro mutant analyses using Dictyostelium, and the emergence of baculovirus as an in vitro system for expression of mutated mammalian myosins.

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页码：89 / 93

页数：5

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