COVALENT MODIFICATION AND METABOLIC CONTROL ANALYSIS - MODIFICATION TO THE THEOREMS AND THEIR APPLICATION TO METABOLIC SYSTEMS CONTAINING COVALENTLY MODIFIABLE ENZYMES

被引：34

作者：

SMALL, JR ^{[1
]}

FELL, DA ^{[1
]}

机构：

[1] OXFORD POLYTECH, SCH BIOL & MOLEC, OXFORD OX3 0BP, ENGLAND

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 191卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1990.tb19136.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study of the sensitivity properties of metabolic systems containing covalently modifiable enzymes and cascades has been carried out with the aid of metabolic control analysis. We have considered how the theorems of metabolic control analysis must be modified to take into account covalently modifiable enzymes, and have used these results to investigate the effects of increasing the total amount of modifiable enzyme. The sensitivity of system variables to an effector acting through a covalent‐modification cycle has also been investigated. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：405 / 411

页数：7

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