RECTAL MUCOSA DAMAGE IN RABBITS AFTER SUBCHRONICAL APPLICATION OF SUPPOSITORY BASES

被引：14

作者：

DEMUYNCK, C

CUVELIER, C

VANSTEENKISTE, D

BONNARENS, L

REMON, JP

机构：

[1] STATE UNIV GHENT, PHARMACEUT TECHNOL LAB, HARELBEKESTR 72, B-9000 GHENT, BELGIUM

[2] VANDEMOORTELE NV, DEPT R&D, B-8870 IZEGEM, BELGIUM

[3] STATE UNIV GHENT HOSP, N GOORMAGHTIGH INST PATHOL ANAT, B-9000 GHENT, BELGIUM

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 07期

关键词：

SUPPOSITORIES; RECTUM; POLYETHYLENE GLYCOL; TRIGLYCERIDE; MONOGLYCERIDE; FATTY ACIDS; ULCER; HYPEREMIA;

D O I：

10.1023/A:1015828201697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of suppository bases on rabbit rectal mucosa was investigated using six triglyceride bases, polyethylene glycol, and a triglyceride base combined with monoglycerides or fatty acids and methyl esters of those acids. Rectal irritation was evaluated and scored according to defined pathological features. "Pure" triglycerides and a triglyceride to which a nonionic surfactant was added caused severe mucosal damage with ulceration and inflammation. Hyperemia was characteristic for irritation by polyethylene glycol suppositories. Mucosal damage by a pure triglyceride combined with monoglycerides or fatty acids and methyl esters of those acids was similar but statistically less pronounced than with all other bases.

引用

页码：945 / 950

页数：6

共 19 条

[1] ANORECTAL ERGOTISM - ANOTHER CAUSE OF SOLITARY RECTAL ULCERS [J].