MARKED INCREASE IN HISTAMINE H-3 RECEPTORS IN THE STRIATUM AND SUBSTANTIA-NIGRA ALTER 6-HYDROXYDOPAMINE-INDUCED DENERVATION OF DOPAMINERGIC-NEURONS - AN AUTORADIOGRAPHIC STUDY

被引：51

作者：

RYU, JH ^{[1
]}

YANAI, K ^{[1
]}

WATANABE, T ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT PHARMACOL 1,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期

关键词：

HISTAMINE H-3 RECEPTOR; 6-HYDROXYDOPAMINE DENERVATION; STRIATUM; SUBSTANTIA NIGRA; UP-REGULATION; LIGAND-BINDING AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(94)90279-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The bindings of [H-3](R)alpha-methylhistamine to histamine H-3 receptors were investigated in rat brain following intranigral treatment with 6-hydroxydopamine (6-OHDA) by quantitative receptor autoradiography. The levels of [H-3](R)alpha-methylhistamine binding sites in the denervated striatum (dorsomedial and dorsolateral) and substantia nigra were significantly higher than those in the contralateral side 21 days after nigral lesions. Saturation kinetic analysis revealed that the maximum binding capacities were up-regulated to about 1.7- and 1.2-fold those in the contralateral substantia nigra and striatum, respectively. These results strongly H-3 receptors in the striatum and substantia nigra are influenced by tonic dopaminergic inputs.

引用

页码：19 / 22

页数：4

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