INVOLVEMENT OF OXIDATIVE AND L-ARGININE-NO PATHWAYS IN THE NEUROTOXICITY OF DRUGS OF ABUSE IN-VITRO

被引：26

作者：

CERRUTI, C

SHENG, P

LADENHEIM, B

EPSTEIN, CJ

CADET, JL

机构：

[1] NIDA,DIV INTRAMURAL RES,MOLEC NEUROPSYCHIAT SECT,BALTIMORE,MD 21224

[2] UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 05期

关键词：

METHAMPHETAMINE; METHYLENEDIOXYMETAMPHETAMINE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PRIMARY CULTURES; SUPEROXIDE DISMUTASE-TRANSGENIC MICE;

D O I：

10.1111/j.1440-1681.1995.tb02025.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Inhibitors of nitric oxide (NO) formation or ADP-ribosylation attenuate methamphetamine (METH)- and methylenedioxymetamphetamine (MDMA)-induced neurotoxicity on dopaminergic and serotonergic cells in primary cultures. 2. They also prevent METH-induced reactive gliosis in dopaminergic cultures. 3. Overexpression of superoxide dismutase (SOD) in cells obtained from SOD-transgenic mice also attenuates drug-induced toxicity. 4. These data indicate a role for oxygen-based and NO free radicals in the mechanisms of cell death associated with drugs of abuse in vitro.

引用

页码：381 / 382

页数：2

共 4 条

[1] CUZN SUPEROXIDE-DISMUTASE (CUZNSOD) TRANSGENIC MICE SHOW RESISTANCE TO THE LETHAL EFFECTS OF METHYLENEDIOXYAMPHETAMINE (MDA) AND OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA) [J].