EXPRESSION OF MESSENGER-RNAS FOR NEUROTROPHINS AND THEIR RECEPTORS IN THE RAT CHOROID-PLEXUS AND DURA-MATER

被引：28

作者：

TIMMUSK, T

MUDO, G

METSIS, M

BELLUARDO, N

机构：

[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,MOLEC NEUROBIOL LAB,S-17177 STOCKHOLM,SWEDEN

[2] UNIV CATANIA,FAC MED,INST HUMAN PHYSIOL,I-95125 CATANIA,ITALY

来源：

NEUROREPORT | 1995年 / 6卷 / 15期

关键词：

CHOROID PLEXUS; DURA MATER; NEUROTROPHINS; TRK RECEPTORS; RNASE PROTECTION ASSAY;

D O I：

10.1097/00001756-199510010-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE presence of the neurotrophin, nerve growth factor, brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 (NGF, BDNF, NT-3 and NT-4) and their receptors of the tyrosine kinase family (trkA, trkB and trkC) have been investigated in the choroid plexus and dura mater of the adult rat by ribonuclease protection assay. The choroid plexus contained high levels of mRNAs for NGF and NT-4, and low levels of NT-3 and BDNF mRNA; and high levels of trkB mRNA, and undetectable levels of trkA and trkC mRNA. In the dura mater there were high levels of NT-3 and NGF, and low levels of BDNF and NT-4 mRNAs; and high levels of trkC mRNA, and relatively high amount of trkB mRNA, while levels of trkA mRNA was undetectable. The present analysis revealed a different distribution of neurotrophins and their related receptors in the choroid plexus and dura mater.

引用

页码：1997 / 2000

页数：4

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