A GOLGI-STUDY OF CELL-TYPES IN THE DENTATE GYRUS OF THE ADULT HUMAN BRAIN

被引：12

作者：

ALHUSSAIN, S

ALALI, S

机构：

[1] Department of Anatomy, Faculty of Medicine, University of Science and Technology, Irbid

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1995年 / 15卷 / 02期

关键词：

HUMAN; DENTATE GYRUS; MOLECULAR LAYER; GRANULE CELL LAYER; HILUS; GOLGI;

D O I：

10.1007/BF02073329

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The morphology of neurons in the dentate gyrus of the adult human brain was analyzed with two variants of Golgi technique. 2. About 20 neuronal types and subtypes were observed in the dentate gyrus of the adult human, several of which had not previously been described in the human, The human dentate gyrus harbors 4 types of neurons in the molecular layer, 3 types within the granule cell layer, and at least 10 types in the hilus. 3. Compared to the granule neurons in the rat brain, human granule neurons show a much greater variability, Many of these human neurons have basal dendrites and/or axonal spines. Also, there are significant differences among these neurons regarding the density of their dendritic trees and dendritic spines. In contrast to the rat, human hilar neurons with complex spines have complex spines not only on their dendrites but also on their cell bodies. 4. This study opens the door for further morphological studies involving specific diseases such as Alzheimer's disease and epilepsy.

引用

页码：207 / 220

页数：14

共 11 条

[1] Amaral D.G., A Golgi study of cell types in the hilar region of the hippocampus in the rat, J. Comp. Neurol., 182, pp. 851-914, (1978)
[2] Braak H., On the structure of the human archicortex: The cornu ammonis, Cell Tissue Res., 152, pp. 349-383, (1974)
[3] Braak E., Strotkamp B., Braak H., Parvalbumin-immunoreactive structures in the hippocampus of the human adult, Cell Tissue Res., 264, pp. 33-48, (1991)
[4] Braitenberg V., Guglielmotti V., Sada E., Correlation of crystal growth with the staining of axons by the Golgi procedure, Stain Technol., 24, pp. 277-283, (1967)
[5] Desmond N.L., Levy W.B., Granule cell dendritic spine density in the rat hippocampus varies with spine shape and location, Neurosci. Lett., 54, pp. 219-224, (1985)
[6] Fox G.A., Ubeda-Purkiss M., Ihrig H.K., Biagioli D., Zinc chromate modification of the Golgi technique, Stain Technol, 26, pp. 109-114, (1951)
[7] Frotscher M., Zimmer J., Lesion-induced mossy fibers to the molecular layer of the rat fascia dentata: Identification of postsynaptic granule cells by the Golgi-EM technique, J. Comp. Neurol., 215, pp. 299-311, (1983)
[8] Frotscher M., Kraft J., Zorn U., Fine structure of identified neurons in the primate hippocampus: A combined Golgi/EM study in the baboon, J. Comp. Neurol., 275, pp. 254-270, (1988)
[9] Ribak C.E., Seress L., Five types of basket cell in the hippocampal dentate gyrus: A combined Golgi and electron microscopic study, J. Neurocytol., 12, pp. 577-597, (1983)
[10] Ribak C.E., Seress L., A Golgi-electron microscopic study of fusiform neurons in the hilar region of the dentate gyrus, J. Comp. Neurol., 271, pp. 67-78, (1988)

← 1 2 →