EFFECT OF COMBINED TOPICAL GLUCOCORTICOIDS AND ULTRAVIOLET-B IRRADIATION ON EPIDERMAL LANGERHANS CELLS

被引：17

作者：

BELSITO, DV

BAER, RL

GIGLI, I

THORBECKE, GJ

机构：

[1] NYU MED CTR, DEPT PATHOL, NEW YORK, NY 10016 USA

[2] UNIV CALIF SAN DIEGO, DIV DERMATOL, SAN DIEGO, CA 92103 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1984年 / 83卷 / 05期

关键词：

D O I：

10.1111/1523-1747.ep12264457

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The combined effect of topical glucocorticoids and ultraviolet B (UVB) irradiation on ATPase+ epidermal Langerhans cells in vivo was investigated in the guinea pig model. Glucocorticoids did not significantly enhance the response to UVB radiation, in the dosage range from 90-550 mJ/cm2 of UVB, suggesting that both agents were acting in a similar fashion. The solvent ethanol potentiated the effect of UVB exposure due, at least in part, to increased penetration of the UVB into the epidermis. The recovery of ATPase+ Langerhans cells was significantly slower after high (> 165 mJ/cm2) than after more moderate doses (90-145 mJ/cm2) of UVB radiation.

引用

页码：347 / 351

页数：5

共 16 条

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