MECHANISMS OF ORGANOPHOSPHATE AND CARBAMATE RESISTANCE IN CULEX-QUINQUEFASCIATUS FROM SAUDI-ARABIA

被引:31
作者
HEMINGWAY, J
CALLAGHAN, A
AMIN, AM
机构
[1] Department of Medical Parasitology, London School of Hygiene and Tropical Medicine
[2] Department of Parasitology, College of Medicine and Allied Sciences, King Abdul Aziz University, Jeddah
关键词
cross‐resistance; Culex quinquefasciatus; Cytochrome P450; esterase; organophosphates; permethrin; propoxur; Saudi Arabia;
D O I
10.1111/j.1365-2915.1990.tb00440.x
中图分类号
Q96 [昆虫学];
学科分类号
摘要
Abstract. Broad spectrum organophosphate resistance in Culex quinquefasciatus Say from Saudi Arabia is inherited as a semi‐dominant characteristic. The resistance has a metabolic basis and confers cross‐resistance against the carbamate propoxur. Organophosphate‐selected strains contain two elevated esterases with the same electrophoretic mobilities as those in resistant Cx quinquefasciatus from Sri Lanka and a range of African locations. Alteration in the sensitivity of acetylcholinesterase to insecticide inhibition does not play a major role in resistance. There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos‐methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos‐methyl. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:275 / 282
页数:8
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