MYOCARDIAL ACCUMULATION OF IODINATED BETA-METHYL-BRANCHED FATTY-ACID ANALOG, [I-125] (P-IODOPHENYL)-3-(R,S)-METHYLPENTADECANOIC ACID (BMIPP), AND CORRELATION TO ATP CONCENTRATION .2. STUDIES IN SALT-INDUCED HYPERTENSIVE RATS

被引:6
作者
FUJIBAYASHI, Y
SOM, P
YONEKURA, Y
KNAPP, FF
TAMAKI, N
YAMAMOTO, K
KONISHI, J
YOKOYAMA, A
机构
[1] KYOTO UNIV, FAC PHARMACEUT SCI,DEPT RADIOPHARMACEUT CHEM, SHIMOADACHI CHO,SAKYO KU, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, KYOTO 606, JAPAN
[3] OAK RIDGE NATL LAB, OAK RIDGE, TN 37830 USA
[4] BROOKHAVEN NATL LAB, DEPT MED, UPTON, NY 11973 USA
关键词
D O I
10.1016/0969-8051(93)90109-8
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This study investigates the possible relationship between myocardial [I-125]BMIPP accumulation and ATP concentration, in the salt-induced hypertensive Dahl-strain rats. [I-125]BMIPP accumulation in the myocardium was inversely related to the degree of hypertension. On the other hand, ATP levels increased in the myocardium of rats with higher blood pressure showing an inverse relationship with BMIPP accumulation. Further studies are required for elucidating these possible inter-related phenomena.
引用
收藏
页码:163 / 166
页数:4
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