A NOVEL METHOD OF MULTIPLE ALIGNMENT OF BIOPOLYMER SEQUENCES

被引：29

作者：

BRODSKY, LI ^{[1
]}

DRACHEV, AL ^{[1
]}

LEONTOVICH, AM ^{[1
]}

FERANCHUK, SI ^{[1
]}

机构：

[1] AN BELOZERSKY PHYS & CHEM BIOL INST,MOSCOW 119899,RUSSIA

来源：

BIOSYSTEMS | 1993年 / 30卷 / 1-3期

关键词：

D O I：

10.1016/0303-2647(93)90063-I

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel algorithm for multiple alignment of biological sequences is suggested. At the first step the DotHelix procedure is employed for construction of motifs, i.e. continuous fragments of local similarity of various ''thickness'' and strength, and then these motifs are concatenated into chains consistent with the order of letters in the sequences. The algorithm is implemented in the MA-Tools program of the GeneBee package. An example illustrating the effectivity of the algorithm is presented.

引用

页码：65 / 79

页数：15

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