EFFECTS OF DIFFERENT ANTIHYPERTENSIVE DRUGS ON PLASMA-FIBRINOGEN IN HYPERTENSIVE PATIENTS

被引:39
作者
FOGARI, R
ZOPPI, A
MALAMANI, GD
MARASI, G
VANASIA, A
VILLA, G
机构
[1] Department of Internal Medicine and Therapeutics, University of Pavia
关键词
HYPERTENSION; FIBRINOGEN; AMLODIPINE; ATENOLOL; HYDROCHLOROTHIAZIDE; LISINOPRIL;
D O I
10.1111/j.1365-2125.1995.tb04482.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 In order to evaluate whether treatment with different antihypertensive drugs would affect plasma fibrinogen levels, 118 mild to moderate essential hypertensive subjects, all males, aged 18 to 65 years, were randomly treated with amlodipine 10 mg, atenolol 100 mg, hydrochlorothiazide 25 mg or lisinopril 20 mg, all given once daily for 8 weeks. 2 Before and after 8 weeks' treatment, blood pressure (BP), heart rate (HR), fibrinogen, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), plasma glucose, plasma uric acid, serum creatinine and serum potassium were evaluated. 3 All four medications significantly reduced BP values, although the BP lowering effect of lisinopril, amlodipine and atenolol was significantly greater compared with that of hydrochlorothiazide. 4 Plasma fibrinogen levels were unaffected by atenolol, hydrochlorothiazide and amlodipine, whereas they were significantly decreased by lisinopril (-11.2%, P = 0.002). This fibrinogen lowering effect was more evident in smokers (-17.7%) than in non smokers (-7.4%). 5 Atenolol and amlodipine did not significantly affect plasma lipids, hydrochlorothiazide increased TC, LDL-C and TG and reduced HDL-C; lisinopril increased HDL-C and decreased TC and LDL-C. 6 Hydrochlorothiazide increased plasma glucose and uric acid concentrations, which were unaffected by the other drugs. The diuretic also reduced serum potassium. 7 The results of this study indicate that lisinopril reduces levels of plasma fibrinogen and confirm that different antihypertensive drugs may elicit different metabolic effects, which may variously influence the overall risk profile of the hypertensive patients.
引用
收藏
页码:471 / 476
页数:6
相关论文
共 46 条
[1]   CAPTOPRIL AND HYDROCHLOROTHIAZIDE - RATIONALE FOR THEIR COMBINATION [J].
AMBROSIONI, E ;
BORGHI, C ;
COSTA, FV .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 23 :S43-S50
[2]   EFFECTS OF DIURETIC DRUGS ON THE LIPID PROFILE [J].
AMES, R .
DRUGS, 1988, 36 :33-40
[3]   AMLODIPINE [J].
BURGES, RA ;
DODD, MG .
CARDIOVASCULAR DRUG REVIEWS, 1990, 8 (01) :25-44
[4]  
CAIMI G, 1983, JPN HEART J, V24, P723
[5]  
CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
[6]  
Costa F V, 1988, Am J Med, V84, P159, DOI 10.1016/0002-9343(88)90226-4
[7]   DRUGS AFFECTING PLASMA-FIBRINOGEN LEVELS [J].
DIMINNO, G ;
MANCINI, M .
CARDIOVASCULAR DRUGS AND THERAPY, 1992, 6 (01) :25-27
[8]  
DORMANDY JA, 1987, CLIN HEMORHEOL, P165
[9]  
ELWOOD PC, 1993, BRIT HEART J, V69, P183
[10]   FIBRINOGEN AS A CARDIOVASCULAR RISK FACTOR - A METAANALYSIS AND REVIEW OF THE LITERATURE [J].
ERNST, E ;
RESCH, KL .
ANNALS OF INTERNAL MEDICINE, 1993, 118 (12) :956-963