OPHIRAPSTANOL TRISULFATE, A NEW BIOLOGICALLY-ACTIVE STEROID SULFATE FROM THE DEEP-WATER MARINE SPONGE TOPSENTIA OPHIRAPHIDITES

被引：22

作者：

GUNASEKERA, SP ^{[1
]}

SENNETT, SH ^{[1
]}

KELLYBORGES, M ^{[1
]}

BRYANT, RW ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,KENILWORTH,NJ 07033

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1994年 / 57卷 / 12期

关键词：

D O I：

10.1021/np50114a024

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described.

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页码：1751 / 1754

页数：4

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