POLYGENIC CONTROL OF SUSCEPTIBILITY TO MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS

被引:419
作者
MOREL, L
RUDOFSKY, UH
LONGMATE, JA
SCHIFFENBAUER, J
WAKELAND, EK
机构
[1] UNIV FLORIDA,COLL MED,DEPT PATHOL & LAB MED,GAINESVILLE,FL 32610
[2] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,ALBANY,NY 12201
[3] UNIV FLORIDA,DEPT STAT,GAINESVILLE,FL 32610
[4] UNIV FLORIDA,COLL MED,DEPT MED,GAINESVILLE,FL 32610
关键词
D O I
10.1016/1074-7613(94)90100-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
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页码:219 / 229
页数:11
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