FATTY-ACID CONTROL OF GROWTH OF HUMAN CERVICAL AND ENDOMETRIAL CANCER-CELLS

被引：20

作者：

GLEESON, RP

AYUB, M

WRIGHT, JT

WOOD, CB

HABIB, NA

SOUTTER, WP

SULLIVAN, MHF

WHITE, JO

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,INST OBSTET & GYNAECOL,DU CANE RD,LONDON W12 0HS,ENGLAND

[2] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON W12 0HS,ENGLAND

[3] ST PETERS HOSP,CHERTSEY KT16 0PZ,SURREY,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 61卷 / 04期

关键词：

D O I：

10.1038/bjc.1990.113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stearic acid and iodo-stearic acid inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 M stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity. © Macmillan Press Ltd., 1990.

引用

页码：500 / 503

页数：4

共 31 条

[1] THE EFFECT OF CELL-DAMAGE ON THE DENSITY AND STEROIDOGENIC CAPACITY OF RAT TESTIS LEYDIG-CELLS, USING AN NADH EXCLUSION TEST FOR DETERMINATION OF VIABILITY [J].